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N Engl J Med (2021) 385(1):e4
While early data looks promising for metabolism research, AOD-9604 is not approved for human or animal use and should only be handled for controlled scientific investigation
10.1111/jne.12643 5 GierB.MatveyenkoA
The clinical evidence supporting tirzepatide and metformin combination therapy comes primarily from large-scale randomized controlled trials, though most were designed to evaluate tirzepatide's efficacy rather than specifically examine synergistic effects with metformin
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