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10.2 Communicating benefits, limits, and safety boundaries Within the current evidence and regulatory framework, GLP-1RA management should be proceduralized using explicit entry points, target goals, and exit rules to minimize uncertainty and risk spillover: The triple-question pre-prescription assessment: before prescribing, clinicians should systematically address three questions: (i) What is the patients metabolic risk tier (BMI/IR, MASLD, glycemic status, etc.)
No clinical trials have evaluated split-dosing regimens
It is meant to be used in combination with diet and exercise
This decline is often associated with a decrease in muscle mass, an increase in abdominal fat, and lower energy levels
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