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Evidence from studies of existing GLP-1-based therapies suggests that weight loss can improve hormonal profiles in women with PCOS, including reductions in androgen levels and improvements in ovulatory function
A larger phase III trial is under way but interim results showed no statistically significant improvement in histological NASH endpoints compared with placebo116
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Given their direct and indirect control of post-prandial nutrient uptake and demonstrated translational relevance for the treatment of type 2 diabetes, malabsorption and cardiometabolic disease, there is significant interest in the locally engaged circuits mediating these metabolic effects
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