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Unlike traditional insulin secretagogues, Prusogliptin does not directly stimulate insulin release but rather enhances endogenous GLP-1 activity, resulting in a lower risk of hypoglycemia and less likelihood of weight gain
The N-terminal region of GLP-1 is considered critical for receptor activation, whereas the C-terminal region predominantly facilitates receptor binding
The purpose of this consensus report is to review the current literature and provide guidelines for diabetes clinicians and people with T1D to facilitate the safe use of GLP-1/GIP RAs in the management of T1D
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