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Wegovy pricing reveals a striking contrast between Canada and the United States, making it markedly cheaper for Canadian patients

Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide) are FDA-approved for chronic weight management in adults with a BMI 30 kg/m, or 27 kg/m with at least one weight-related comorbidity

In comparison to the marked differences between N-terminally substituted exendin-4 agonist responses, differential effects on binding kinetics, -arrestin recruitment, internalization, and recycling were relatively modest within these licensed compounds, albeit statistically significant in some cases (Fig