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10.1016/S0140-6736(71)92415-9
The upregulation of Glp1r mRNA may potentially compensate for the lack of increase in OB GLP-1 release in obese mice
Gradually increase your fiber intake through fruits, vegetables, and whole grains, aiming for 25-30 grams daily
For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results
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