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At the same time, in our previous study on the protective effect of Ebselen on renal ischemia-reperfusion injury, we found that the expression level of GPX3 in renal tissues decreased after renal IRI, and when the level of GPX3 increased after the use of Ebselen, the pathological damage of renal histologic damage was alleviated, and we speculated that GPX3 may play an important role in the oxidative stress response of renal ischemia-reperfusion injury (Wu et al., 2022)

Before combining medications, discuss optimizing your current therapy by ensuring adequate dosing and treatment duration, exploring FDA-approved alternatives like tirzepatide or phentermine-topiramate ER, intensifying lifestyle interventions with behavioral therapy, or considering metabolic surgery if you meet clinical criteria