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Description

The remodeling of T-tubules destroys accurate communication between L-type voltage-gated Ca 2+ channels (VGCCs), located predominantly on the T-tubule membrane, and type 2 ryanodine receptor (RyR2), a Ca 2+ -release channel located on the sarcoplasmic reticulum (108)

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In a study of 3,731 patients assigned to take either liraglutide or placebo, 63.2% of patients taking liraglutide lost at least 5% of their body weight and 33.1% of patients lost at least 10% of their body weight

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