tirzepatide studies after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial Tirzepatide 10mg | Research-Grade Dual

That makes the latest research all the more exciting: Early, observational work in postmenopausal women suggests that pairing GLP-1s with hormone replacement therapy may result in greater weight loss than GLP-1s alone

Patients should be advised to: Inspect feet daily for injuries, blisters, or colour changes Wear well-fitting footwear and avoid walking barefoot Maintain good foot hygiene and moisturise dry skin (avoiding between toes) Seek same-day assessment by the multidisciplinary foot care service for any new foot wounds, signs of infection, or sudden changes in foot shape Attend annual diabetes reviews incorporating the Nine Care Processes, including foot screening Referral to specialist services is appropriate when: Neuropathic pain remains inadequately controlled despite optimised primary care management Diagnostic uncertainty exists regarding neuropathy aetiology, or features are atypical or rapidly progressive Foot ulceration, infection, or suspected Charcot arthropathy develops (same-day referral to multidisciplinary foot care service per NICE NG19) Severe infection or critical limb ischaemia (emergency hospital admission) Severe autonomic symptoms significantly impair quality of life Patient engagement through diabetes self-management education empowers individuals to optimise lifestyle factors including diet, physical activity, and smoking cessationall contributing to improved metabolic control and reduced complication risk

It happens when your body can't make the extra insulin it needs during pregnancy

An early study of 2,000 obese adults compared people using semaglutide plus a diet and exercise program with people who made the same lifestyle changes without semaglutide