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Most incretin weight-loss therapies are injected subcutaneously, but oral semaglutide is already licensed in the UK for T2DM as Rybelsus, while its manufacturer Novo Nordisk has published positive phase III results (OASIS-4, NCT05564117) for its 25mg semaglutide pill for weight loss 6
Zinman B, Bhosekar V, Busch R et al (2019) Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial
They are commonly used for B12 injections in areas like the deltoid or gluteal muscles
The 5-on/2-off idea borrows from GH-therapy practice and is presented as a documented option, not a proven-better method
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