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Naltrexone alone has modest weight effects but may enhance outcomes when paired with behavioral interventions
Both Nirchi and Long point to things like nausea and constipation, particularly when starting the drugs or titrating up to a higher dose (but for them, the benefits have outweighed the downsides)
Key Takeaways PCOS creates a metabolic trap: insulin resistance drives weight gain, and weight gain worsens insulin resistance Tirzepatide's dual GIP/GLP-1 mechanism directly targets the insulin resistance at the core of PCOS Clinical trials show 15-22% body weight loss with tirzepatide, with particular benefits for insulin-resistant patients Benefits extend beyond the scale: improved androgen levels, restored ovulation, and reduced cardiovascular risk Tirzepatide may be more effective than semaglutide for PCOS due to its additional GIP receptor activity Table of Contents Have PCOS and Struggling to Lose Weight
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