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Nevertheless, these represent only the first pieces of evidence, and numerous aspects, including the durability of effects, the interplay between signaling pathways, and the potential for synergistic or antagonistic interactions, remain to be clarified by future studies

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A small, preliminary study suggested that SAMe (S-adenosylmethionine) slightly reduced pain at rest and fatigue, but not pain during physical activity, depression, or sleep among people with fibromyalgia