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The interplay between gut microbiota, bile acids, glucose homeostasis, and systemic immune responses is an emerging field that could uncover common therapeutic targets across multiple musculoskeletal diseases. The evolving understanding of OA as more than a mechanical disorder, along with insights into the gut-joint axis, bile acid metabolism, and GLP-1 signaling, highlight a pivotal shift in the foundational understanding of the condition, which can be utilized to develop new, more effective therapeutic interventions that could significantly improve patient outcomes.

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