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This is consistent with GHK-Cus known role in upregulating collagen synthesis in dermal fibroblasts, a mechanism confirmed in a comprehensive review in Biomolecules documenting GHK-Cus influence across more than 4,000 human genes involved in tissue remodeling and repair

A meta-analysis of 13 clinical trials that included 421 patients with stage 25 CKD who did not require dialysis found that up to three months of exercise therapy resulted in a significant increase in eGFR compared with no exercise intervention

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