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Extreme sun exposure without protection, over-exfoliation, strong cleansers, and active chemical usage can all damage it

However, AuNPs are not degraded in the brain, and accumulating too many of them can lead to cellular mitochondrial damage and disrupt the integrity of the BBB[120]

Keatings lab spent many years designing peptides that would bind to the section of Mcl-1 involved in this interaction but not to other members of the protein family

developed a physiologically relevant microfluidic model of three-dimensional human neuronal cell culture that recapitulates the same key BBB dysfunction as in AD patients[210]