Adjunctive basal GLP-1-RA therapy in patients after MBS may be a promising treatment choice in weight management in addition to lifestyle changes, not only due to increased GLP-1 signaling, but also to a putative blunting effect on metabolic adaptation that occurs after MBS, increased fat oxidation, and decreased carbohydrate and protein oxidation
The Big Decision Point: 612 Months Heres where the journey can go in different directions: If youve hit your goal: Taper off slowly (going cold turkey often leads to weight regain) If youre still losing: Many stay on another 36 months Hard truth: Around 80% of people regain some weight when stopping completely The Unspoken Truth Your Doctor Might Not Mention Theres no one-size-fits-all answer
If BCBS denies coverage of Zepbound, even after your healthcare provider provides evidence of medical necessity, consider calling your insurer directly and asking for a case manager
In addition, in a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity, without affecting centrally regulated anxiety-like behaviors [56]