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A pooled analysis of 5 randomized placebo-controlled trials demonstrated a significant 13% reduction in the risk of total stroke with GLP-1 RAs compared with placebo, without significant heterogeneity between trials
Nothing here is a dosing recommendation, a titration schedule, or administration guidance it is a summary of published trial findings and must not be used to guide personal use of any compound
Once-weekly dosing improves adherence compared to daily oral medications, and sustained receptor activation produces consistent appetite suppression
Systematic reviews and meta-analyses suggest modest benefits for glycaemic control and lipid profiles in people with type 2 diabetes or metabolic syndrome, but the overall quality of evidence is considered moderate at best
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