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A 2026 review in the American Journal of Sports Medicine emphasizes that despite popularity, "significant research regarding the safety and efficacy of these therapeutic methods is required before definitive recommendations can be made to patients." Only a single human case series exists for BPC-157 (for knee pain), with significant methodological flaws and no controls
Worse, doctors will often stop treatment altogether when blood levels seem okay
Children at risk for developing osteoporosis should have a DEXA scan when they enter long-term follow-up care
[17] [21] Surgical interventions are considered when: Medical management fails to control symptoms adequately Fertility is a primary concern Endometriomas (ovarian cysts) or severe adhesions are present Deep infiltrating endometriosis affects bowel or bladder Laparoscopic excision or ablation of endometriotic lesions, performed in specialist endometriosis centres, can provide significant symptom relief
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