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Under these conditions, we measured a decrease in insulin secretion in response to exendin-4 versus vehicle conditions, primarily due to elevated basal secretion levels at 11 mM glucose (Figure 1E, F), confirming that increased cholesterol levels reduce the GLP-1R glucoregulatory potential by decreasing its capacity to potentiate islet insulin secretion

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Conclusion L-carnitine represents a quaternary ammonium compound with critical roles in cellular bioenergetics, particularly facilitating -oxidation processes involving fatty acids

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