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It has also established baseline databases, follow-up databases, and a biobank covering the natural populations across five provinces and cities in the Southwest region, marking a major breakthrough in large-scale natural population cohort research in multi-ethnic areas of Southwest China

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These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46