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Meta-analysis data revealed that the frequency of the MTHFR 1298C allele is higher in Asians (36.040.0%), followed by Caucasians (33.035.0%) and Brazilians (23.025.0%) (Victorino et al., 2014)
These people may need vitamin B12 shots to reduce their risk of deficiency, which can lead to pernicious anemia
doi: 10.1056/NEJM197002052820604 137
Notably, many polyphenols also exhibit circadian activity e.g., resveratrol can activate the SIRT1 pathway which influences the clock, and quercetin can modulate clock gene expression in cells
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