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Mechanistic insights from sequential combination therapy with a sodium glucose co-transporter-2 inhibitor and a dipeptidyl peptidase4 inhibitor: results from the CANARIS Trial using canagliflozin and teneligliptin

Specifically, using GLOW as the control arm and KLOW as the treatment arm isolates KPVs contribution to inflammatory resolution, cell survival, and barrier function without confounding the angiogenic and matrix components present in both formulations

Evidence from animal models indicates that CP can modify microbial balance and inflammation-related taxa, linking these effects to improvements in obesity- and diabetes-associated parameters (Reference Steele5)

Prioritising adequate sleep and managing stress are key components of metabolic health