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Due to their porous microstructure, hydrogels in particular have a high loading capacity 22,23,24,25

Unlike retraglutide, which targets three receptors, semaglutide only targets one-the GLP-1 receptor

Reasons to Consider Trulicity Insurance/formulary requirements: Your insurance covers Trulicity but not Ozempic Step therapy requires trying Trulicity first Formulary preference makes Trulicity significantly less expensive Device preference: Strong needle phobia that Trulicitys hidden needle addresses Significant dexterity limitations making Trulicitys device easier Preference for simpler device operation Provider familiarity: Your provider is more experienced with Trulicity Established care relationship involves Trulicity Previous experience: Known tolerance of dulaglutide Previous success with Trulicity Concerns about switching established treatment Specific circumstances: Part of a comprehensive treatment plan designed around dulaglutide Provider has specific clinical reasons to prefer dulaglutide Reasons Ozempic Is Usually Better Greater effectiveness: Approximately 0.4% better HbA1c reduction Approximately twice the weight loss Higher proportion of patients reaching treatment targets Weight loss priority: Significant weight to lose Metabolic benefits of weight loss important Weight-related health conditions (sleep apnea, joint pain, etc.) Cardiovascular considerations: Potentially greater cardiovascular protection (26% vs

Equally, Nooms clinician-designed protocol recognizes that a higher dose isnt always better for every patient