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A 2021 review of 16 randomized trials found B12 does not reliably reduce fatigue in people who are not deficient
Oral B12 supplements rely on a complex absorption pathway in the gut involving a protein called intrinsic factor
When to Seek Medical Advice About B12 Side Effects Whilst mild, transient gastrointestinal symptoms from vitamin B12 supplements rarely require urgent medical attention, certain situations warrant prompt consultation with a healthcare professional
The formulation and inactive ingredients often play a more significant role than the vitamin itself in causing digestive disturbances
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