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The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death (Martinou and Green, 2001
Melegh B, Kerner J, Sandor A, et al
The visible result: dull skin, loss of firmness, fine lines, and a weakened barrier that can't protect itself properly
10.1016/j.abb.2005.12.014 Arch
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