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The disease is called pernicious ( deadly ), because before scientists first isolated B12 (after which, shots became available), it was lethal
This can also be treated by pre-dosing the recipient with either IVIg to accelerate catabolism of the endogenous IgG pool or rituximab to deplete Ab-producing B cells [362,363,364]
The generation of tolerogenic DCs by VIP may lead to the production of CD4+ and CD8+ Treg cells, which display a typical cytokine profile of high IL-10 and TGF-, and minimal or no IFN- and IL-2
Although it may sound like a single condition, Ehlers-Danlos Syndromes (EDS) are a heterogeneous group of hereditary disorders of connective tissue, with common features including joint hypermobility, soft and hyperextensible skin, abnormal wound healing, and easy bruising
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