Recruitment of glutathione into the nucleus during cell proliferation adjusts whole-cell redox homeostasis in Arabidopsis thaliana and lowers the oxidative defence shield
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This stabilizes the transcription factor BACH1, which subsequently upregulates angiogenesis-related factors, including PDGFB, EGFR, FGF2, and FGFR1, ultimately driving vascular regeneration
Pharmacological interventions that restored catalase levels helped reestablish mitochondrial integrity and barrier function in endothelial cells (Wang S