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Data reveal that early non-responders receiving phentermine achieved 5.9% weight loss compared to just 2.8% with placebo after 24 weeks, with over half reaching the clinically meaningful threshold of 5% weight reduction

It is **not considered a therapeutic dose for significant weight loss.** While some individuals might notice subtle changes in appetite or feeling slightly fuller during this first month, significant weight loss is generally not expected at this dose

Some patients notice the symptom returns briefly if they increase their dose, but tolerance typically develops within 23 weeks of the new dose level

A person starting at 220 pounds, for example, may lose around 22 to 33 pounds over several months