Available: Xie, N., Zhang, L., Gao, W., Huang, C., Huber, P.E., Zhou, X., Li, C., Shen, G., Zou, Bingwen, NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential, Signal Transduction and Targeted Therapy
Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose
It results in feeling fuller for longer, even when consuming less food
It has been studied for its effects on sleep architecture, particularly delta wave (slow-wave) sleep patterns