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When GLP-1 receptor agonists are used with insulin or sulfonylureas, there is an increased risk of hypoglycaemia, and dose reductions of these medications may be needed

These results underscore the need for future studies with larger sample sizes, and measurements of potential confounders, especially weight and biomarkers (i.e., HbA1c) to confirm our findings

There is no robust clinical evidence showing that semaglutide directly reduces cortisol levels, and it should not be used for this purpose

However, we cannot entirely rule out that this reduction in E max may be linked to differences in efficiency of receptor expression (Kunath et al., 2003)