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The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary
WHR, waisttohip ratio
However, healthy individuals synthesise glutathione endogenously at rates sufficient to meet this demand if dietary intake of cysteine, glutamate, and glycine is adequate
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