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Metoclopramide demonstrates mixed results due to central nervous system side effects and limited upper gastrointestinal effectiveness [64]
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Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression
The effects on gastric emptying are reported to be reduced with long-term use
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