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In PsO, clinical studies evaluating GLP-1RAs such as liraglutide and semaglutide have reported significant improvements in PASI scores and histopathological skin features, effects that appear to be at least partially independent of weight loss ( Given the prominent role of IL-17driven inflammation in obese PsA patients, GLP-1RAs may also enhance the efficacy of biologic agents targeting these pathways
The high prices of semaglutide and tirzepatide currently limit access, while liraglutides expired patent has allowed for more affordable generic versions to become available
Initially approved for the treatment of type 2 diabetes, these medications have more recently demonstrated efficacy in supporting weight loss
operations and global business development, said during Wednesdays earning call
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