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When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed
The recommendations above are for the cyanocobalamin form of B12 which is the form used for most fortified foods and many supplements
Mixing peptides together can destabilize both compounds and reduce effectiveness
5, May 2010, pp
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