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[88] [89] In contrast to these population studies, a review of randomized trials using supplementation with either vitamin K 1 or vitamin K 2 reported no role in mitigating vascular calcification or reducing arterial stiffness

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Based on previous studies, we expected a decrease to occur in the total number of hepatocytes in the HFD rats in contrast to the control group, which might be explained by attributing to this fact that the number of binucleated hepatocytes is significantly increased in MAFLD concurrent with the disease progression as a result of a compensatory response to the decreased number of hepatocytes due to necrotic alterations 71

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