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A laboratory analysis published in Expert Opinion on Drug Safety on April 30, 2026, examined samples of compounded tirzepatide mixed with B12 obtained from various sources in the U.S

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In a pool of two ZEPBOUND clinical trials for weight reduction (Studies 1 and 2), severe gastrointestinal adverse reactions were reported more frequently among patients receiving ZEPBOUND (5 mg 1.7%, 10 mg 2.5%, 15 mg 3.1%) than placebo (1%)

Receive Your Shot : If Vitamin B12 shots are recommended, the healthcare provider will administer the injection