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The resulting holoenzyme dimer comprising the two subunits is catalytically more efficient and less subject to inhibition by GSH than GCLC alone
Five studies involving 825 exposed pregnancies and 592,714 comparator pregnancies evaluated first-trimester exposure and major congenital malformations
The participant in the group supplemented with choline showed an 12-25% increase of the elicited imitation memory paradigm, 8% higher verbal IQ, 29% higher visual-spatial reasoning, 36% higher crossmodal learning, 27% higher non-verbal working memory 4 years after the treatment at a mean of 8.6 year of age
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