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SURMOUNT-5 trial: 5.9% mean weight loss Glapp users: 7.5% mean weight loss Relative improvement: +27.1% Key insight: Over the first 12 weeks, digitally engaged semaglutide users achieved approximately 2530% greater weight reduction compared to clinical trial participants receiving identical pharmacotherapy

Emerging research also continues to explore how GLP-1 pathways interact with reward signaling in the brain

Pretreatment with GLP-1(2836) reduces infarct size in mice and provides direct GLP-1Rindependent cardioprotection in isolated mouse hearts