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Community Med
Metabolism 36 , 11921196 (1987)
Agmatine enhances Wnt/-catenin signaling by inhibiting Rnf128-mediated -catenin ubiquitination, thereby upregulating targets such as Cyclin D1, Lgr5, CD44, and c-Myc [162], while 5-aminovaleric acid (5-AVA) derived from Fusobacterium mortiferum similarly activates this pathway through suppression of the tumor suppressor DKK2 [163]
However, because of its ability to antagonize peripheral thyroxine receptors, L-carnitine should probably not be given to hypothyroid dogs
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