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Lupus in MRL/lpr mice was improved by GLS1 inhibition or deficiency
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The activation of mitogen-activated protein kinase (MAPK) cascades comprising three tiers of kinasesthe MAPK kinase kinase (MAPKKK/MEKK), the MAPK kinase (MAPKK/MKK) and the MAPK (MPK)upon MAMP perception represents a conserved innate immune signalling event in metazoans and plants 3
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