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Subsequent mass spectrometry analysis of biotin-captured proteins revealed that FBXO22 was the strongest interactor
The first readout, TRIUMPH-1 (obesity), was reported on 21 May 2026, with 28.3% mean weight loss at 80 weeks in the 12mg cohort (Pharmaceutical Journal)
This mechanism likely originates from microbial-derived bioactive molecules that enter systemic circulation to regulate physiological processes in distal organs (Melndez-Oliva et al., 2025)
References Amato G, Conte M, Mazziotti G, Lalli E, Vitolo G, Tucker AT, Bellastella A, Carella C, Izzo A (2003) Serum and follicular fluid cytokines in PCOS during stimulated cycles
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