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switch to a hydrophilic statin (rosuvastatin, pravastatin) if myalgias localize SGLT2 inhibitors: reinforce hydration targets (minimum 2.5 L daily) Laxatives or stimulant bowel preps: reduce frequency if already experiencing GLP-1-related diarrhea Tier 3: Low risk but worth documenting ACE inhibitors (can rarely cause cramps through unclear mechanisms) Beta-agonist inhalers (albuterol can lower serum potassium at high doses) The Endocrine Society's 2023 clinical practice guideline on pharmacologic management of obesity recommends monitoring electrolytes during the titration phase of anti-obesity medications, with particular attention to patients on concurrent diuretic therapy 9

10.1016/j.cub.2014.03.034 92 ShiY.WeiB.LiL.WangB.SunM

Elevated GH levels increase lipolysis, the process of breaking down stored fats into free fatty acids, which the body can then use as energy

In the TRIUMPH-4 trial, participants on the 12 mg dose of retatrutide lost an average of 71.2 pounds over 68 weeks