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El inicio debe ser con dosis bajas y se va aumentando en forma progresiva en funcin de la tolerancia, para evitar los efectos adversos
This sequential approach serves two purposes: first, to eliminate immortal time bias by properly aligning treatment initiation with follow-up start (T0) and, second, to maximize statistical power by allowing individuals to contribute data across multiple trials
CL and KW conducted to the data analysis and manuscript drafting for this work
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