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Therefore, the interpretation of related findings should return to verifiable key variables, including dose and time window, tissue niche, cell lineage origin, as well as substrate competition and transporter expression levels ( From the perspective of the evidence hierarchy, current studies on amino acid metabolism-mediated regulation of macrophage polarization are still derived mainly from in vitro polarization models and animal experiments
In conclusion, Phase II enzymes are an interesting research field since they play an essential role in the metabolism of hundreds of foreign compounds as well as in regulation of metabolism and disposition of various endogenous biologically active substances and thus maintaining homeostasis in the human body
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