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The competition between Eli Lilly and Novo Nordisk dominates headlines, but behind them a wave of challengers, from Amgen to upstart biotechs, are probing new mechanisms and formulations
Preclinical studies in rodent models of cortical contusion and ischemia/reperfusion injury consistently demonstrate that riboflavin administration (typically 120 mg/kg oral or parenteral) reduces lesion volume, brain edema, astrocytosis, and apoptotic cell death, while enhancing sensorimotor recovery and spatial memory performance (56)
116 MariM.ColellA.MoralesA.CaballeroF.MolesA.FernandezA.et al (2008)
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