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( g ) Energy expenditure recorded in metabolic cages (with ANCOVA using BW as covariate) and ( h ) corresponding ambulatory activity ( g , h : CON VEH n = 6, CON acyl-GIP n = 4, Gipr AP-KO n = 6, Gipr AP-KO n = 4)

This peptide is derived from human growth hormone (hGH) and contains a disulfide bridge

Tail vein blood glucose concentrations were measured using a handheld glucometer (Contour XT, Bayers) at 0, 15, 30, 60 and 120 min after injection (for the Mc4r KO study a 90 min timepoint was also included)