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The mechanisms underlying IGF-1's tendon repair effects involve activation of the IGF-1 receptor on tenocytes and tendon stem cells, leading to enhanced extracellular matrix synthesis, improved cellular migration to injury sites, and optimized remodeling of repair tissue
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Miao Cai, Ph.D., from the VA Saint Louis Health Care System, and colleagues examined whether initiation of GLP-1 receptor agonists is associated with a reduced risk for incident SUDs in people with no history of SUD (protocol 1) or with a reduced risk for SUD-related adverse clinical outcomes among people with a preexisting SUD (protocol 2)
Active cancer, pregnancy, and uncontrolled diabetes change the answer
