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Eligibility and contraindications Each of these medications comes with eligibility criteria, but these drugs are generally indicated for: Adults who have obesity (BMI of 30 or above) Adults who have overweight (BMI of 27 or above) as well as a weight-related comorbid condition, such as high blood pressure, type 2 diabetes, and obstructive sleep apnea Some groups of people should not take these medications, including: People who are pregnant People with a personal or family history of medullary thyroid cancer People who have a known serious hypersensitivity to the ingredients in the medication Additionally, you should not use these medications in combination or with other weight loss medications