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SAM is produced within the body and obtains its required methyl group from methylcobalamin underlining the importance of methylcobalamin as a central supplier of methyl groups
Excess vitamin B12 is linked to increased cancer growth in certain types of cancer.[ref] Methotrexate, a chemotherapy drug, works by inhibiting the production of methyl folate, thus limiting methionine and DNA synthesis for cell growth
It means it didn't work well enough as a standalone pharmaceutical drug
(Study: Zinman et al., 2019) Administration: Mounjaro is administered orally, typically once daily, making it convenient for patients
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