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However, it may be challenging to accurately control the dosage or adjust it to specific needs

However, treatment with curcumin in PCOS rats significantly reduced ROS ( p = 0.005) and malondialdehyde ( p = 0.004) levels while increasing superoxide dismutase ( p = 0.04), glutathione peroxidase ( p = 0.002), and glutathione ( p = 0.02) levels in ovarian tissues ( Figure 5 )

After a steepest descent minimization (5,000 steps), the systems were equilibrated in several steps ((1) 500-ps simulation with constant number of particles, volume and temperature, and with a time step of t = 0.5 fs